Vitamin D may exacerbate autoimmune disease

Deficiency in vitamin D has been widely regarded as contributing to autoimmune disease, but a review appearing in Autoimmunity Reviews explains that low levels of vitamin D in patients with autoimmune disease may be a result rather than a cause of disease and that supplementing with vitamin D may actually exacerbate autoimmune disease. Like corticosteroid medications, vitamin D may provide short term relief by lowering inflammation but may exacerbate disease symptoms over the long term.

The insights are based on molecular research showing that 25 D inactivates rather than activates its native receptor the Vitamin D nuclear receptor or VDR. Once associated solely with calcium metabolism, the VDR is now known to transcribe at least 913 genes and largely control the innate immune response by expressing the bulk of the body’s antimicrobial peptides, natural antimicrobials that target bacteria.

Written under cheap jerseys the guidance of professor Trevor Marshall of Murdoch University, Western Australia, the paper contends that 25 D’s actions must be considered in light of recent research on the Human Microbiome. Such research shows that bacteria are far more pervasive than previously thought 90% of cells in the body are estimated to be non human increasing the likelihood that autoimmune diseases are caused by persistent pathogens, many of which have yet wholesale jerseys to be named or have their DNA characterized.

Marshall and team explain that by deactivating the VDR and subsequently the immune response, 25 D wholesale jerseys china lowers the inflammation caused by many of these bacteria but allows them to spread more easily in the long run. They outline how long term harm caused by high levels of 25 D has been missed because the bacteria implicated in autoimmune disease grow very slowly. For example, a higher incidence in brain lesions, allergies, and atopy in response to vitamin D supplementation have been noted only after decades of supplementation with the secosteroid.

Furthermore, low levels of 25 D are frequently noted in patients with autoimmune disease, leading to a current consensus that a deficiency of the wholesale nfl jerseys secosteroid may contribute to the autoimmune disease process. However, Marshall and team explain that these low levels of 25 D are a result, rather than a cause, of the disease process. Indeed, Marshall’s research shows that in autoimmune disease, 25 D levels are naturally down regulated in response to VDR dysregulation by chronic pathogens. Under such circumstances, supplementation with extra vitamin D is not only counterproductive but harmful, as it slows the ability of the immune system to deal with such bacteria.

autoimmune disease continues to escalate.”For the past five years, Autoimmunity Research Foundation has been running an observational study in which patients are administered pulsed low dose antibiotics and a VDR agonist in order to kill chronic bacteria implicated in their diseases. Specific data on the cohort was recently presented by CAPT Thomas H. Perez, USPHS (ret) at the International Congress on Autoimmunity in Porto, Portugal:Presentation on clinical data:.Articles Connexes：

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